Schedule I · misdemeanor possession
South Carolina lists psilocybin in Schedule I. A first simple-possession offense is a misdemeanor punishable by up to six months and a $1,000 fine.
SC legal and access quick reference
Reviewed July 21, 2026Psilocybin law and access in South Carolina
A concise, source-dated explanation of statewide law, regulated access, and the difference between state and local policy.
Laws and implementation can change quickly. This page is educational information, not legal advice.
No enacted public access program
South Carolina has no statewide personal-use, retail, dispensary, or regulated psilocybin service program.
Controlled · no statewide access program
Research, study proposals, or scheduling bills do not create legal personal use, commercial sales, or regulated services.
What local policy means
For Charleston, Columbia and Greenville, this South Carolina page is the appropriate quick-reference starting point because no separate municipal action was retained as a distinct local-policy guide. Local rules can change, so verify current official records.
Cities covered by the South Carolina guide
The statewide explanation above covers Charleston, Columbia and Greenville. A separate page appears below only where a documented municipal action adds material local context.
CharlestonCovered in South Carolina guide
ColumbiaCovered in South Carolina guide
GreenvilleCovered in South Carolina guide
Sources used for this review
This page was checked against the controlling state statutes, enacted laws, agency records, and official bill histories listed below.
Common questions
Is psilocybin legal in South Carolina?
No. South Carolina lists psilocybin in Schedule I. A first simple-possession offense is a misdemeanor punishable by up to six months and a $1,000 fine. No statewide public-access program has been enacted.
Does South Carolina have a regulated psilocybin access program?
No. South Carolina has not enacted a statewide psilocybin personal-use, retail, dispensary, or regulated service program.
Do city policies change South Carolina law?
No. A local enforcement-priority policy may affect municipal enforcement, but it does not legalize commercial sale, create statewide legality, or override federal law.
Continue at the right depth
The product-site link provides product-format and business-policy information. It does not change the law described on this page or establish legal access in any jurisdiction.